Design and in silico screening of aryl allyl mercaptan analogs as potential histone deacetylases (HDAC) inhibitors
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چکیده
منابع مشابه
Histone Deacetylases and their Inhibitors as Potential
treatment regimen is still an unmet need. This might lead to the fact that few CCA patients are suitable for the surgery as well as the limitation of other therapeutic modalities (Patel, 2006; Sia et al., 2013; Zabron et al., 2013). In addition, the palliative chemotherapy and radiotherapy have been used as adjuvant therapy for this cancer type. Various chemotherapeutic agents e.g. 5-fluorourac...
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Histone deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets for cancer and other diseases. Different subtypes of HDACs appear to play disparate roles in the cells and are associated with specific diseases. Therefore, substantial effort has been made to develop subtype-selective HDAC inhibitors. In an effort to discover ...
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Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly influenced by the post-translational modification of histones, the building blocks of chromatin, such as methylation, phosphorylation and acetylation. Acetylation is probably the best understood of these modifications: hyperacetylation leads to an increase in the expression of particular genes, and hypoa...
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that have been identified as a promising target to reverse aberrant epigenetic states associated with cancer via the regulation of acetylation levels in histone. Aberrant histone acetylation has been observed in the development of numerous malignancies, and HDAC inhibitors (HDACIs) are a promising new treatment strategy for malignant disease. The hydroxamic acid trichostatin A (TSA) have been k...
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ژورنال
عنوان ژورنال: Heliyon
سال: 2020
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2020.e03517